Proportion of LEW and F344 rats that showed substitution (>80% cocaine-appropriate responding) for various drugs in the cocaine discrimination study
| Drug | Dose | F344 | Lewis |
|---|---|---|---|
| Cocaine | 0.3 | 1 /6 | 1 /8 |
| 1 | 4 /6 | 4 /8 | |
| 3 | 5 /6 | 5 /8 | |
| 10 | 6 /6 | 6 /7 | |
| Amphetamine | 0.1 | 0 /6 | 0 /7 |
| 0.3 | 4 /6 | 4 /7 | |
| 1 | 4 /6 | 3 /7 | |
| Pentobarbital | 1 | 0 /5 | 0 /6 |
| 3 | 0 /5 | 1 /7 | |
| 10 | 1 /5 | 1 /6 | |
| Quinpirole | 0.001 | 0 /8 | 0 /8 |
| 0.01 | 0 /8 | 1 /8 | |
| 0.1 | 7 /8 | 6 /8 | |
| SKF 38393 | 0.1 | 0 /5 | 0 /7 |
| 1 | 0 /5 | 0 /7 | |
| 10 | 0 /5 | 0 /7 |