Supersensitivity of AChE knockout mice to VX and DFP
| AChE Genotype | AChE Activity | VX LD50 | DFP |
|---|---|---|---|
| μg/kg | 2.5 mg/kg i.p. | ||
| AChE+/+ | 100% | 24 | All lived (n = 8) |
| AChE+/− | 50% | 17 | 7 died, 8 lived |
| AChE−/− | 0% | 10–12 | All died (n = 3) |
DFP results are from Xie et al. (2000).