Table 2

Effect of delayed treatment with GPI5232 to reduce infarct volume following 2 h of MCAo and 22 h of reperfusion

TreatmentTotal InfarctCortical InfarctSubcortical Infarct
mm3
30-mg/kg i.v. bolus followed by 6-mg/kg i.v. infusion × 4 h, 60 min post-MCAo
 Vehicle (n = 11)209  ± 15172  ± 1237  ± 5
 GPI5232 (n = 9)105  ± 172-160 86  ± 142-160 19  ± 62-160
 %Neuroprotection50%50%48%
30-mg/kg i.v. bolus followed by 6-mg/kg i.v. infusion × 4 h, 120 min post-MCAo
 Vehicle (n = 10)237  ± 34193  ± 2844  ± 6
 GPI5232 (n = 10)128  ± 292-150 108  ± 242-150 21  ± 62-150
 %Neuroprotection47%44%53%
30-mg/kg i.v. bolus followed by 6-mg/kg i.v. infusion × 4 h, 180 min post-MCAo
 Vehicle (n = 9)203  ± 40168  ± 3336  ± 7
 GPI5232 (n = 10)148  ± 36121  ± 2927  ± 8
 %Neuroprotection27%28%24%

All infarct volumes are presented as the mean ± S.E.M. Total infarct = cortical + subcortical infarct. %Neuroprotection represents the reduction in infarct volume as compared with the vehicle-treated group.

  • ↵2-150  p < 0.05,

  • ↵2-160  p < 0.01, analysis of variance followed by Dunnett's post hoc test.