Table 2

Effect of daily treatments on glutamate uptake and life span of wild-type and familial ALS transgenic mice

Mouse	Treatment	Glutamate Uptake in Spinal Cord at 150 Days		Grip Test at 150 Days		Life Expectancy
Mouse	Treatment	n	K_m	V_max	n	G	n
	mg/kg/day s.c.		μM	nmol/mg protein/min				days
Wild-Type	Saline	16	1.80 ± 0.06	0.58 ± 0.03	29	387 ± 19	10	>200
	RPR at 3	N.D.	N.D.	N.D.	11	374 ± 25 N.S.	11	>200
Familial ALS Transgenic Mice	Saline	19	1.81 ± 0.05	0.32 ± 0.18^2-c	27	167 ± 11^2-c	50	158 ± 2
	RPR at 1	N.D.	N.D.	N.D.	9	121 ± 18 N.S.	11	161 ± 4 N.S.
	RPR at 3	16	1.94 ± 0.07	0.50 ± 0.21^2-b	17	280 ± 20^2-b	49	169 ± 2^2-b
	RPR at 2 × 3	10	1.86 ± 0.05	0.46 ± 0.19^2-a	17	281 ± 15^2-b	25	178 ± 4^2-b

N.D., not determined.
↵2-a Significantly different from saline-treated familial ALS transgenics, P < 0.01.
↵2-b Significantly different from saline-treated familial ALS transgenics, P < 0.001.
↵2-c Significantly different from saline-treated wild-type animals, P < 0.001.