Table 1

Collection schedule of dependent measures during the experimental sessions

	Time	Visual Analogs	Subject-Rated Adjectives	Observer-Rated Adjectives	ARCI	Manual Respiratory Rate	Pupil Photographs
	min
Pretreatment period (all sessions)^1-a	−45	X	X	X	X	X	X
Enadoline, butorphanol, or placebo (i.m.)	−30
	−25	X				X	X
	−15	X	X	X	X	X	X
	−5	X				X	X
Cocaine dose-effect sessions only (Monday)
Cocaine (0, 20, and 40 mg i.v.)	0
	0–14	X
	5					X	X
	10						X
	15		X	X	X	X	X
	30	X	X	X		X	X
	45	X	X	X		X	X
Cessation cocaine self-administration sessions only (Wednesday)
Cocaine sample (40 mg i.v.)	0
	0–4	X
	5						X
	10	X
	15	X	X	X	X	X	X
Cessation and relapse self-administration sessions (Wednesday and Friday)
Six choice trials: cocaine versus money	0^1-b	^1-c
	0–4	X
	5	^1-c		X		X	X
	10	X	X	X		X	X

↵1-a On-line measures for heart rate, blood pressure, oxygen saturation, and skin temperature were collected throughout all experimental sessions.
↵1-b Time 0 represents the start of each 15-min trial.
↵1-c Administered only if cocaine was chosen over money.