Table 1

Structure of MCH analogs

Peptide12345678910111213141516171819
MCH1-a AspPheAspMetLeuArgCysMetLeuGlyArgValTyrArgProCysTrpGlnVal
Salmon MCH1-a Asp Thr Met ArgCysMet Val GlyArgValTyrArgProCysTrp Glu Val
[F13;Y19]-MCH1-a AspPheAspMetLeuArgCysMetLeuGlyArgVal Phe ArgProCysTrpGlnTyr
C1AspPheAspMetLeuArg Ser MetLeuGlyArgValTyrArgPro Ser TrpGlnVal
MCH6–17 ArgCysMetLeuGlyArgValTyrArgProCysTrp
S36077Arg Ser MetLeuGlyArgValTyrArgPro Ser Trp
C2ArgCys Ala LeuGlyArgValTyrArgProCysTrp
C3ArgCysMetLeuGlyArg Ala TyrArgProCysTrp
C4ArgCysMetLeuGlyArgVal Ala ArgProCysTrp
C5ArgCysMetLeuGlyArgValTyr Ala ProCysTrp
C6ArgCysMetLeuGly His ValTyrArgProCysTrp
C7ArgCysArgValTyrArgProCysTrp
C8ArgCysMetLeuArgValTyrArgProCysTrp
S36057Tyr(I)ADOArgCysMetLeuGlyArgVal Phe ArgProCysTrp

All compounds except C1 and S36077 are cyclic peptides between Cys7 and Cys16; substituted residues are in bold.

  • Tyr(I), 3-iodotyrosine; ADO, 8-amino-3,6-dioxyoctanoyl.

  • 1-a  Commercially available.