Table 2

Effect of PTZ (1 mM) on single-channel properties of human α1β2γ2 recombinant GABA_A receptors (outside-out patches were voltage-clamped at −40 mV)

	5 μM GABA	⁺1 mM PTZ
Open frequency (s⁻¹)	15.9 ± 6.7	8.1 ± 3.7^2-150
Open probability	0.05 ± 0.02	0.03 ± 0.01^2-150
Open time
τ1 (ms)	2.52 ± 0.30	2.35 ± 0.36
A1	0.77 ± 0.09	0.86 ± 0.03^2-150
τ (ms)	12.67 ± 3.2	11.70 ± 1.9
A2	0.23 ± 0.09	0.14 ± 0.03^2-150
Close time
τ1 (ms)	2.63 ± 0.38	2.69 ± 0.30
A1	0.43 ± 0.05	0.38 ± 0.03^2-150
τ2 (ms)	26.6 ± 8.9	43.6 ± 12.8^2-150
A2	0.32 ± 0.07	0.23 ± 0.04^2-150
τ3 (ms)	202.9 ± 73.4	356.4 ± 140.1^2-150
A3	0.25 ± 0.07	0.39 ± 0.06^2-150
Mean current amplitude (pA)	−1.49 ± 0.02	−1.48 ± 0.03
Number of openings	4247	2515
Number of patches	6	6

↵2-150 p < 0.05, compared to the control, paired Student's t test; τ, time constant; A, relative area.