Table 2

Effect of α₃-isoform antibody on membrane potential of locus ceruleus neurons in brain slices with whole-cell patching^2-a

	Resting Membrane Potential		Depolarization Induced by Antibody
	Without Antibody^2-b	With Antibody^2-c	Depolarization Induced by Antibody
	mV
Placebo	−63.4 ± 0.9 (18, 10)	−49.7 ± 1.4	13.7 ± 1.3
Tolerant	−57.7 ± 2.3 (14, 8)^2-150	−47.9 ± 2.1	9.8 ± 1.1^2-150
Difference	5.7	1.8	3.9

Numbers in parentheses represent number of cells and number of animals.

↵2-150 p < 0.05 vs. placebo.
↵2-a Patch pipettes contained 20 mM Na⁺.
↵2-b Recorded immediately after whole-cell patching.
↵2-c Recorded 1 to 1½ h after whole-cell patching, after the antibody was able to dialyze into the cell.