Mean ED50 values and 95% CLs of positive GABAAmodulators substituting for midazolam (0.56 mg/kg)
| Drug | Midazolam Substitution ED50 | 95% CL |
|---|---|---|
| mg/kg | ||
| Nonselective BZ | ||
| Midazolam | 0.16 | (0.05–0.28) |
| Triazolam | 0.07 | (0.05–0.09) |
| Diazepam | 2.80 | (2.20–3.40) |
| BZ1-selective | ||
| Zaleplon | 0.64 | (0.52–0.77) |
| Zolpidem | 1.76 | (0.84–2.90) |
| Neuroactive steroid | ||
| Pregnanolone | 6.40 | (4.26–8.98) |
| Barbiturate | ||
| Amobarbital | 19.46 | (14.06–25.22) |
| Pentobarbital | 20.89 | (14.47–29.20) |