Oral administration of CT52923 inhibits carotid artery neointima formation in rat balloon injury model
| Dosage (per day) | No. of Animals | Area | I/M Ratio | % Reduction of I/M Ratio | |
|---|---|---|---|---|---|
| Media | Intima | ||||
| mm2 | |||||
| Control | 8 | 0.130 ± 0.0033-a | 0.124 ± 0.011 | 0.94 ± 0.08 | |
| 10 mg/kg | 8 | 0.125 ± 0.003 | 0.122 ± 0.009 | 0.97 ± 0.06 | −3 |
| 30 mg/kg | 8 | 0.122 ± 0.004 | 0.100 ± 0.011 | 0.80 ± 0.08 | 15 |
| 60 mg/kg | 7 | 0.128 ± 0.006 | 0.099 ± 0.008 | 0.76 ± 0.06 | 19 |
| (p < 0.05) | |||||
| 100 mg/kg | 8 | 0.124 ± 0.002 | 0.086 ± 0.008 | 0.69 ± 0.06 | 27 |
| (p < 0.01) | (p < 0.05) | ||||
↵3-a The values for area and intima/media (I/M) ratio are presented as mean ± S.E.M.