Emetogenic effects of YM976 and other compounds in ferrets
| Compound | Dose | n | Ferrets Showing Emesis | Incidence | |
|---|---|---|---|---|---|
| 0–0.5 h | 0.5–8 h | ||||
| mg/kg p.o. | % | ||||
| Control | 8 | 0 | |||
| YM976 | 3 | 3 | 0 | ||
| 10 | 8 | 0 | |||
| 30 | 6 | a, b | a | 33 | |
| 100 | 4 | c, c | c, d | 50 | |
| Rolipram | 1 | 5 | 0 | ||
| 3 | 5 | e, f, g | e, f | 60 | |
| 10 | 5 | h, i, j, k | h, i, j | 80 | |
| RP73401 | 1 | 3 | 0 | ||
| 3 | 6 | l, m | l, m, n, o | 67 | |
| 10 | 3 | p, q, r | p, q | 100 | |
| CDP840 | 10 | 4 | 0 | ||
| 30 | 6 | r, s, t, u, v | r, s, t | 83 | |
| 100 | 2 | w, x | w, x | 100 | |
Each compound was administered orally at a volume of 3 ml/kg to fasted ferrets. One ferret was administered only one compound. Data are expressed as the identity numbers of ferrets showing emesis at 0 to 0.5 and 0.5 to 8 h and the incidence (%) of emesis. The letters (e.g., a, b, and c, etc.) show the identity numbers of the respective ferrets.