Table 8

Summary of the pharmacological properties of SL651498 in rodents

Tests	MED (^*ED₅₀) i.p. (p.o.)
Tests	SL651498	Diazepam	Clorazepate	Lorazepam
	mg/kg
Isoniazid-induced convulsions in mice	7^*	0.7^*	2^*	2^*
PTZ-induced convulsions in mice	9.5^*	0.3^*	0.4^*
Electroshock-induced convulsions in mice	≈40^*	1.5^*	2.5^*
Lever-pressing conflict test in rats	3	2.5	3
Drinking conflict test in rats	10 (10)	1 (10)	10 (10)	0.1
Elevated plus-maze in rats	1 (3)	3 (20)	10 (10)	0.1 (1)
Light/dark test in mice	10	2	2	1
Four-plate test in mice	4	(2)
Mouse defense test battery	3 (3)	0.5 (1)	10
Rotarod in mice	100	10	3	1
Rotarod in rats	30	10	1	0.3
Grip Strength in mice	56^*	3.5^*		0.6^*
Grip Strength in rats	27^*	2.9^*		0.3^*
EEG in rats	30 (30)	1		0.1
Horizontal wire test in mice	(>30)	(1)
Interaction with alcohol in mice	(30)	(1)

Comparison with diazepam and other BZs (unpublished data).