Effect of miconazole, clotrimazole, and glybenclamide on fast and slow current components
| Itocomponent | Amplitude | Time Constants | n | |||
|---|---|---|---|---|---|---|
| control | drug | control | drug | |||
| pA/pF | ms | |||||
| Miconazole (30 μM) | fast | 30.8 ± 5.00 | 28.4 ± 3.36 | 103 ± 20.3 | 32 ± 5.21-150 | 6 |
| slow | 31.0 ± 4.00 | 7.3 ± 1.641-150 | 1145 ± 100.2 | 988 ± 190.7 | ||
| offset | 15.4 ± 2.63 | 17.4 ± 6.92 | ||||
| Clotrimazole (30 μM) | fast | 15.3 ± 3.89 | 15.8 ± 3.78 | 104 ± 18.7 | 58 ± 12.11-150 | 4 |
| slow | 15.4 ± 1.12 | 10.4 ± 2.501-150 | 1291 ± 39.7 | 1771 ± 256.4 | ||
| offset | 11.6 ± 2.75 | 11.1 ± 3.09 | ||||
| Glybenclamide (50 μM) | fast | 25.5 ± 3.40 | 11.0 ± 1.291-150 | 102 ± 14.7 | 61 ± 7.01-150 | 9 |
| slow | 24.2 ± 4.22 | 10.6 ± 1.981-150 | 1167 ± 82.2 | 1405 ± 187.1 | ||
| offset | 15.7 ± 1.95 | 12.9 ± 1.84 | ||||
Components of Ito were resolved by fitting the current decay with a sum of two exponentials (Materials and Methods). Data are given as mean ± standard error of the mean.
↵1-150 P < 0.05 versus control using two-tailed paired t test.