Sham (n = 6) | Untreated ARF (n = 6) | ARF + Lactacystin | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0.1 mg/kg (n = 5) | 1 mg/kg (n = 5) | |||||||||||||||||||
Histopathological | − | ± | + | ++ | +++ | − | ± | + | ++ | +++ | − | ± | + | ++ | +++ | − | ± | + | ++ | +++ |
Changes/grade | (0 | 1 | 2 | 3 | 4) | (0 | 1 | 2 | 3 | 4) | (0 | 1 | 2 | 3 | 4) | (0 | 1 | 2 | 3 | 4) |
Tubular necrosis | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 3 | 0 | 0 | 1 | 4 | 0 | 1 | 4 | 0 | 0 | 0 |
(3.33 ± 0.33) | (2.80 ± 0.20) | (0.80 ± 0.20)1-a | ||||||||||||||||||
Proteinaceous casts in tubuli | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5 | 0 | 0 | 0 | 1 | 4 | 0 | 0 | 3 | 2 | 0 | 0 |
(3.83 ± 0.14) | (2.80 ± 0.20) | (1.40 ± 0.24)1-a | ||||||||||||||||||
Medullary congestion | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4 | 0 | 0 | 0 | 3 | 2 | 0 | 0 | 4 | 1 | 0 | 0 |
(2.67 ± 0.21) | (2.40 ± 0.24) | (1.20 ± 0.20)1-b |
Data are expressed as the number of animals with histopathological changes. Values in parentheses represent the mean ± S.E.M. of histopathological change/grade. Grades: no change (−, 0), mild (±, 1), moderate (+, 2), severe (++, 3), very severe (+++, 4).