General animal characteristics and cardiovascular parameters in control and MCT-treated animals
| Parameter | Untreated | Cariporide | ||
|---|---|---|---|---|
| Control (n = 18) | MCT (n = 20) | Control (n = 18) | MCT (n = 22) | |
| Baseline BW (g) | 273 ± 7.6 | 262 ± 3.1 | 272 ± 3.1 | 267 ± 3.6 |
| Δ BW (g) | 153 ± 5.7 | 25 ± 6.51-165 | 147 ± 5.5 | 50 ± 4.21-165 1-151 |
| HR (beats/min) | 363 ± 11 | 386 ± 13 | 352 ± 15 | 376 ± 11 |
| MAP (mm Hg) | 113 ± 4.6 | 78 ± 61-165 | 111 ± 4.5 | 91 ± 51-160 |
| LVSP (mm Hg) | 132 ± 3.3 | 98 ± 4.61-165 | 135 ± 3.4 | 107 ± 4.31-165 |
Values represent means ± S.E.M.
Baseline BW, body weights immediately prior to MCT administration; Δ BW, increase in body weight over the 3-week follow-up period. All other values were obtained 3 weeks after MCT administration. HR, heart rate; LVSP, left ventricular systolic pressure; MAP, mean arterial pressure.
↵1-160 P < 0.01,
↵1-165 P < 0.001 from respective control value;
↵1-151 P < 0.05 from MCT untreated group.