Table 3

Specific binding of [3H]LY341495 to multiple regions of the rat brain using quantitative autoradiography

Rat Brain RegionMean ± S.E. (n= Five Rats)
fmol/mg
Amygdala761.5  ± 6.3
Globus pallidus279.3  ± 30.2
Lateral geniculate nuclei706.1  ± 24.4
Access. olfactory bulb1254.1  ± 45.9
Anterior olfactory nucleus785.8  ± 29.4
Olfactory tubercle1027.4  ± 39.8
Frontal ctx, layers I&II1456.2  ± 37.3
Frontal ctx, layer III1331.6  ± 69.1
Frontal ctx, layers IV&V1029.9  ± 78.3
Occipital ctx, layers I&II1532.6  ± 41.2
Occipital ctx, layer III1269.4  ± 69.2
Occipital ctx, layers IV&V1011.2  ± 38.1
Retrosplenial ctx1498.9  ± 62.8
Presubiculum1225.4  ± 39.5
Subiculum664.1  ± 37.9
Lacunosum moleculare hippo.1345.4  ± 78.4
Oriens, hippocampus590.8  ± 25.4
Pyramidal layer, hippocampus509.2  ± 32.7
Stratum radiatum, hippocampus564.7  ± 22.6
Dentate gyrus, granular613.4  ± 14.3
Dentate gyrus, molecular1223.6  ± 54.5
Caudate/putamen1025.6  ± 34.0
Nucleus accumbens1078.0  ± 22.1
Lateral dorsal/lateral posterior thalamus nuclei860.4  ± 50.5
Ventral thalamus nuclei521.0  ± 15.2
Substantia nigra573.6  ± 39.9
Inferior colliculus297.7  ± 16.6
Superior colliculus601.7  ± 28.4
Deep mesencephalic nuclei212.1  ± 39.0
Cerebellar granular layer759.0  ± 17.8
Cerebellar molecular layer438.0  ± 20.9
Interposed cerebellar nuclei53.1  ± 0.0