Table 4

Effects of S-5751 and S-1452 on antigen-induced increase in the number of inflammatory cells in bronchoalveolar lavage fluid in guinea pig asthma model

Challenge	Compound	Dose	n	Cell Number (×10⁶/animal)
Challenge	Compound	Dose	n	Total Cells	Eosinophils	Macrophages
		mg/kg
Saline			4	3.2 ± 0.5	1.5 ± 0.4	1.6 ± 0.2
Antigen	Vehicle		5	17.1 ± 2.2^4-167	5.0 ± 0.6^4-167	10.3 ± 1.5^4-167
	S-5751	10	6	9.7 ± 2.3^4-150	2.9 ± 0.7^4-150	5.6 ± 1.4^4-150
Saline			8	3.0 ± 0.3	0.5 ± 0.1	2.1 ± 0.2
Antigen	Vehicle		6	12.1 ± 1.9^4-167	4.2 ± 0.8^4-167	5.1 ± 0.7^4-167
	S-1452	10	8	13.8 ± 1.7	4.9 ± 0.7	5.7 ± 0.9

Bronchoalveolar lavage performed 24 h after the last antigen challenge, respectively. S-5751 and S-1452 were orally administered 1 and 2 h before antigen challenge, respectively.

Statistical significance.
↵4-167 P < 0.01 versus saline challenge by Student's t test.
↵4-150 P < 0.05 versus vehicle control by Dunnett's test.