Table 3

Effect of S-5751 and BW A868C on antigen-induced increase in the number of inflammatory cells in nasal lavage fluid in guinea pig allergic rhinitis model

Challenge	Compound	Dose	n	Cell Number (×10⁴/animal)
Challenge	Compound	Dose	n	Total Cells	Eosinophils
		mg/kg
Pretreatment
Saline			6	10.9 ± 2.7	1.4 ± 0.4
Antigen	Vehicle		12	60.2 ± 9.0^3-167	38.4 ± 6.6^3-167
	S-5751	1	9	36.0 ± 6.7^3-150	22.0 ± 4.7
		3	10	24.9 ± 5.5^3-160	14.0 ± 3.6^3-160
		10	12	17.5 ± 3.7^3-160	8.9 ± 2.0^3-160
Saline			5	6.8 ± 1.2	1.1 ± 0.2
Antigen	Vehicle		11	22.4 ± 4.5^3-159	13.4 ± 3.5^3-159
	BW A868C	1	11	9.1 ± 2.2^3-150	3.8 ± 1.0^3-150
Post-treatment
Saline			8	4.1 ± 1.0	0.4 ± 0.1
Antigen	Vehicle		8	54.5 ± 11.0^3-167	34.1 ± 7.4^3-167
	S-5751	1	8	27.7 ± 4.0^3-150	15.8 ± 2.4^3-160
		3	8	19.1 ± 2.5^3-160	8.1 ± 1.5^3-160
		10	8	12.1 ± 2.9^3-160	5.7 ± 1.6^3-160

Nasal lavage was performed 5 h after the last antigen challenge. S-5751 was orally administered 1 h before antigen challenge and BW A868C was intravenously given 10 min before challenge. In the study for investigating the inhibitory action of post-treatment with S-5751 on inflammatory cell infiltration, S-5751 was administered 2 h after the antigen challenge.

Statistical significance.
↵3-159 P < 0.05,
↵3-167 P < 0.01 versus saline challenge by Student's t test.
↵3-150 P < 0.05,
↵3-160 P< 0.01 versus vehicle control by Dunnett's test.