ED50 values of S-5751, BW A868C, S-1452, and antihistamines for DP-, TP-, and H1 receptor-mediated responses in guinea pigs
| Receptor | Stimuli | Tissue | Response | ED50Values | |||
|---|---|---|---|---|---|---|---|
| S-5751 p.o. | BWA868C i.v. | S-1452 p.o. | Ketotifen (K) or Terfenadine (T) p.o. | ||||
| mg/kg | |||||||
| DP | PGD2 | Conjunctiva | Dye exudation | 0.099 | 0.12 | >30 | >30 (K) |
| TP | U-46619 | Conjunctiva | Dye exudation | >10 | >1 | 0.017 | >30 (K) |
| U-46619 | Lung | Bronchoconstriction | >30 | >1 | 0.006 | >10 (T) | |
| H1 | Histamine | Conjunctiva | Dye exudation | >30 | N.T. | N.T. | 0.003 (K) |
| 0.45 (T) | |||||||
| H1 | Histamine | Lung | Bronchoconstriction | >30 | >1 | >3 | 2.3 (T) |
S-5751, S-1452, ketotifen, and terfenadine were orally administered to guinea pigs 1, 2, 1, and 2 h before stimulation, respectively, and BW A868C was intravenously given 10 min before stimulation.
N.T., not tested.