Previously called | α1C
| − | α1A/D, α1A
|
Species cloned | Human, rat, mouse, rabbit, dog, pig, guinea pig, bovine | Human, rat, mouse, guinea pig, hamster | Human, rat, mouse, pig, rabbit |
Binding |
Selective antagonists (>50×) | (+)Niguldipine, 5-methylurapidil KMD-3213 | − | BMY 7378 |
Signaling |
PLC, PLA2, PLD, Ca2+, K channels, MAPKs | Coupling efficiency +++
+
|
++
|
+
|
Desensitized internalized |
++
|
+++
| ± |
Protein (amino acids) | 465 (rat), 466 (human) | 515 (rat), 519 (human) | 560 (rat), 572 (human) |
Characteristic tissues (rat) | Vasculature, vas deferens, urethra, submaxillary gland | Liver, spleen | Aorta, iliac, femoral arteries |
Cellular localization | Cell surface and intracellular | Cell surface | Mostly intracellular |