Table 1

Pharmacokinetic parameters of organic mononitrates in rats

ParameterIIMNIMMN2-ISMN5-ISMN
V 3 or V 4 (liter kg−1)0.757  ± 0.2110.607  ± 0.0870.755  ± 0.1211.21  ± 0.131-a
k 30or k 40 (min−1)0.0430  ± 0.00371-a 0.0207  ± 0.00341-a 0.0120  ± 0.00241-a 0.00550  ± 0.000681-a
CL30 or CL40 (liter min−1 kg−1)0.0320  ± 0.00701-a 0.0126  ± 0.00301-b 0.00903  ± 0.002000.00657  ± 0.000351-b

Each value represents the mean ± S.D. of nine rats administered 200, 100, or 50 mg/kg dose.

  • ↵1-a  Significantly different from the values of other isomers (P < 0.05).

  • ↵1-b  Significantly different from the values of isomers except for 2-ISMN (P < 0.05).