Effect of TLK199 on GM-CFU in mouse bone marrow
| % Control GM-CFU | ||
|---|---|---|
| GSTπ−/− | GSTπ+/+ | |
| Ex vivo concentration of TLK199 (μM) | ||
| 0 | 100 ± 2 | 100 ± 3 |
| 1.0 | 102 ± 7 | 125 ± 17 |
| 2.5 | 101 ± 8 | 148 ± 153-150 |
| 10.0 | 98 ± 2 | 184 ± 63-150 |
| In vivo dose of TLK199 (mg/kg) | ||
| 0 | 100 ± 6 | 100 ± 4 |
| 50 | 106 ± 12 | 156 ± 83-150 |
| 75 | 107 ± 9 | 194 ± 223-150 |
↵3-150 Data are significantly different from control (P < 0.02).