Inhibition of arachidonate and eicosanoids by BMS-229724 in inflammatory cells
| Cell | Agonist | Lipid Mediator Measured | IC50 with BMS-229724 |
|---|---|---|---|
| μM | |||
| Platelets, human | Thrombin | Arachidonate | 4 |
| Neutrophils, human | LTB4 | Arachidonate | 12 |
| Neutrophils, human | A23187 | LTB4 | 3 |
| Mast cells, mouse | Antigen | Arachidonate | 3 |
| Monocytes, human | LPS | PGE2 | 6 |
| Keratinocytes, human | A23187 | PGE2 | 8 |
| Neutrophils, human | A23187 | Platelet- activating factor | 15 |
See Experimental Procedures for details.