Magnitude and reversal time of coronary dilation caused by various adenosine receptor agonists in open-chest anesthetized pigs
| Agonist | Dose | CBF (Fold-Increase) | t0.5 | t0.9 | n |
|---|---|---|---|---|---|
| μg/kg/min | min | ||||
| CVT-3146 | 10 | 3.40 ± 0.04 | 1.9 ± 0.2 | 10.1 ± 0.7 | 3 |
| CVT-3146 | 30 | 3.83 ± 0.39 | 2.6 ± 0.5 | 12.3 ± 1.1 | 6 |
| CVT-3032 | 30 | 3.78 ± 0.70 | 2.3 ± 0.6 | 9.6 ± 1.0 | 3 |
| CVT-3033 | 50 | 3.33 ± 0.58 | 3.1 ± 0.9 | 12.0 ± 1.0 | 3 |
| WRC0470 | 1 | 3.14 ± 0.24 | 9.5 ± 0.8 | 22.5 ± 1.6 | 6 |
| CGS21680 | 2 | 3.54 ± 0.09 | 9.7 ± 0.8 | 21.4 ± 0.8 | 3 |
| YT-146 | 1 | 3.44 ± 0.47 | 17.8 ± 3.4 | 32.9 ± 5.6 | 3 |
Maximal fold-increase and time (min) to 50 and 90% (t0.5 and t0.9, respectively) reversal of the increases in coronary blood flow caused by various adenosine receptor agonists. Data represent mean ± S.E.M. of one or two measurements in each of n pigs.