Table 2

Pharmacokinetics parameters obtained following i.v. administration (1 mg/kg) or p.o. administration (3 mg/kg) of nifedipine to rats administered vehicle, FCD ⁺ Oxo, or FCD for 4 consecutive days

Parameters	i.v. Administration		p.o. Administration
Parameters	Vehicle	FCD ⁺ Oxo	FCD	Vehicle	FCD ⁺Oxo	FCD
AUC (ng · h/ml)	1947 ± 242	2569 ± 488	2223 ± 425	2698 ± 297	3232 ± 685	4983 ± 600^2-150
t _1/2 (hr)	0.44 ± 0.13	0.43 ± 0.16	0.36 ± 0.16	0.65 ± 0.20	0.83 ± 0.18	0.75 ± 0.21
CL (ml/hr/kg)	521 ± 70	404 ± 97	467 ± 115
C _max(ng/ml)				938 ± 262	994 ± 265	1827 ± 447^2-160
F (%)				46.2	41.9	74.7

The rats were administered vehicle FCD ⁺ Oxo, and FCD for 4 consecutive days. Results are expressed as mean (± S.D.);n = 5 per group.

F: the bioavailability was calculated by the following equation: (AUC_p.o./Dose_p.o.)/(AUC_i.v./Dose_i.v.) × 100.
↵2-160 P < 0.01 and
↵2-150 P < 0.001, compared with the values in the vehicle-treated group.