CYP-dependent regio- and stereo-selective testosterone hydroxylation by liver microsomal enzymes in rats administered vehicle, FCD + Oxo, or FCD for 4 consecutive days
| Treatment | Testosterone Hydroxylase Activity | |||||
|---|---|---|---|---|---|---|
| 6α | 7α | 6β | 16α | 16β | 2α | |
| nmol/min/mg | ||||||
| Vehicle | 0.114 ± 0.020 | 0.233 ± 0.036 | 1.902 ± 0.356 | 3.778 ± 0.460 | 0.148 ± 0.024 | 2.350 ± 0.326 |
| FCD +Oxo | 0.099 ± 0.023 | 0.207 ± 0.026 | 1.706 ± 0.418 | 3.771 ± 0.644 | 0.146 ± 0.029 | 2.387 ± 0.342 |
| FCD | 0.098 ± 0.023 | 0.287 ± 0.062 | 2.037 ± 0.293 | 3.491 ± 0.449 | 0.178 ± 0.032 | 2.136 ± 0.225 |
Each value represents the mean ± S.D. (n = 5).