Table 1

Effect of BMS-191095 on pre- and postischemic cardiac function in isolated rat hearts

PredrugPostdrugReperfusion 30 min
Heart rate (beats/min)
 Vehicle305  ± 10293  ± 8272  ± 21
 0.3 μM BMS-191095298  ± 13290  ± 8285  ± 24
 1 μM BMS-191095309  ± 9289  ± 6299  ± 6
 3 μM BMS-191095305  ± 8293  ± 10301  ± 10
 6 μM BMS-191095309  ± 20300  ± 18310  ± 13
 10 μM BMS-191095297  ± 9268  ± 21270  ± 23
 6 μM BMS-191095 + 1 μM glyburide282  ± 8280  ± 13273  ± 15
 6 μM BMS-191095 + 100 μM 5-HD294  ± 5282  ± 2278  ± 10
LVDP (mm Hg)
 Vehicle127  ± 4117  ± 411  ± 21-a
 0.3 μM BMS-191095131  ± 6116  ± 419  ± 31-a
 1 μM BMS-191095131  ± 4121  ± 435  ± 61-a 1-b
 3 μM BMS-191095130  ± 4119  ± 452  ± 61-a 1-b
 6 μM BMS-191095129  ± 10116  ± 1160  ± 81-a 1-b
 10 μM BMS-191095133  ± 3103  ± 81-b 31  ± 41-a 1-b
 6 μM BMS-191095 + 1 μM Gly135  ± 5138  ± 712  ± 21-a
 6 μM BMS-191095 + 100 μM 5-HD138  ± 4136  ± 415  ± 51-a

All values are mean ± S.E.

  • ↵1-a  Significantly different than its respective predrug value (P < 0.05).

  • ↵1-b  Significantly different from its respective vehicle group value (P < 0.05).