Biochemical parameters in treated rats
| Control (n = 10) | Cisplatin (n = 6) | Bamet-R2 (n = 4) | Bamet-UD2 (n = 4) | |
|---|---|---|---|---|
| Blood | ||||
| Red blood cells (×106)/μl | 6.8 ± 0.3 | 6.8 ± 0.2 | 7.6 ± 0.6 | 7.9 ± 0.6 |
| Packed cell volume (%) | 40.6 ± 1.6 | 40.3 ± 0.9 | 44.1 ± 2.3 | 46.4 ± 3.3 |
| Hemoglobin (g/100 ml) | 13.7 ± 0.5 | 13.9 ± 0.3 | 15.3 ± 0.7 | 15.3 ± 0.8 |
| White blood cells (×103)/μl | 5.5 ± 0.7 | 3.5 ± 0.22-a | 4.8 ± 0.5 | 5.2 ± 1.0 |
| Platelets (×103)/μl | 975 ± 31 | 714 ± 832-a | 1073 ± 86 | 1035 ± 24 |
| Serum | ||||
| Urea (mg/dl) | 30.3 ± 3.0 | 106 ± 252-a | 62 ± 12 | 26.0 ± 2.7 |
| Creatinine (mg/dl) | 0.6 ± 0.1 | 1.0 ± 0.22-a | 0.7 ± 0.1 | 0.5 ± 0.1 |
| Total bilirubin (mg/dl) | 0.40 ± 0.05 | 0.63 ± 0.09 | 0.45 ± 0.09 | 0.53 ± 0.09 |
| GOT-ASAT (UI/l) | 123 ± 24 | 121 ± 11 | 193 ± 34 | 114 ± 8 |
| GPT-ALAT (UI/l) | 27.7 ± 3.3 | 19.2 ± 3.7 | 17.0 ± 3.4 | 27.2 ± 2.7 |
| AP (UI/l) | 526 ± 75 | 436 ± 82 | 504 ± 85 | 535 ± 66 |
| Glucose (mg/dl) | 199 ± 19 | 263 ± 46 | 207 ± 29 | 239 ± 33 |
| Urine | ||||
| Urea (mg/dl) | 3103 ± 619 | 1993 ± 546 | 1968 ± 402 | 2477 ± 700 |
| Creatinine (mg/dl) | 108 ± 15 | 58 ± 13 | 78 ± 8 | 83 ± 20 |
| Na+(mmol/l) | 93 ± 21 | 59 ± 9 | 75.5 ± 12.3 | 60 ± 16 |
| K+ (mmol/l) | 330 ± 47 | 173 ± 39 | 184 ± 22 | 221 ± 45 |
| Cl− (mmol/l) | 182 ± 27 | 111 ± 23 | 131 ± 22 | 128 ± 24 |
| Creatinine clearance (ml/min) | 1.9 ± 0.2 | 1.0 ± 0.22-a | 1.4 ± 0.1 | 2.0 ± 0.2 |
Values are expressed as means ± S.E. from rats treated with 10 i.p. doses (once every 4 days) of cisplatin, Bamet-R2, or Bamet-UD2 (7.5 nmol/g of body weight).
AP, alkaline phosphatase; GOT-ASAT, glutamic-oxalacetic transaminase-aspartate aminotransferase; GPT-ALAT, glutamic-pyruvic transaminase-alanine aminotransferase.
↵2-a p < 0.05, compared with control animals by the Bonferroni method of multiple-range testing.