Ki | |||
---|---|---|---|
Cloned Rat m1 | Rat Heart | Cloned rat m3 | |
Compound A | 1.7 ± 0.32 | 420 ± 17 | 2.6 ± 0.13 |
(1/1.5, 0.92) | (160, 0.99) | (1, 0.95) |
The K i values were calculated by the method of Cheng and Prusoff (1973) and are presented as the mean ± S.E. of three experiments. The values in parentheses indicate the selectivity of binding affinity against cloned rat m3 receptor and the value of Hill slope, respectively.