Table 1

Potency of IDN-1965 by multiple routes of administration in the α-Fas model of liver injury

Route of Administration	ED₅₀	95% Confidence Intervals
	mg/kg
i.p.	0.14	0.06–0.34
i.v.	0.04	0.02–0.09
p.o.	1.25	0.45–3.52

α-Fas was administered i.v. (200 μg/kg) and immediately following injection, mice were treated with either saline vehicle or IDN-1965 (0.003–3 mg/kg). Mice were killed 6 h after α-Fas administration, and ALT activities were measured in plasma.