D1-like receptor binding after 4 weeks of continuous infusion of antipsychotic drugs
| Brain Region | Controls | Olanzapine | Risperidone | Quetiapine | Clozapine 1-a | Fluphenazine 1-a |
|---|---|---|---|---|---|---|
| Cerebral cortex | ||||||
| Medial-prefrontal | 14.0 ± 0.5 (100) | 13.3 ± 0.6 (95) | 11.9 ± 1.5 (85) | 15.5 ± 1.0 (107) | (93) | (102) |
| Dorsolateral | 7.5 ± 0.9 (100) | 6.2 ± 0.8 (82) | 9.0 ± 0.8 (120) | 8.2 ± 0.8 (109) | (100) | (96) |
| Nucleus accumbens | 85.7 ± 4.1 (100) | 86.0 ± 4.3 (100) | 88.4 ± 7.3 (103) | 81.1 ± 6.0 (95) | (92) | (96) |
| Caudate-putamen | ||||||
| Medial | 87.6 ± 7.1 (100) | 90.0 ± 10.3 (103) | 78.0 ± 4.6 (99) | 74.8 ± 7.2 (85) | (99) | (101) |
| Lateral | 90.9 ± 7.9 (100) | 98.8 ± 11.6 (109) | 78.4 ± 4.3 (103) | 83.3 ± 6.3 (92) | (91) | (104) |
| Hippocampus | 7.5 ± 1.0 (100) | 8.6 ± 0.5 (115) | 8.3 ± 0.7 (111) | 8.9 ± 0.6 (119) | ||
| Entorhinal cortex | 10.8 ± 0.7 (100) | 11.3 ± 1.1 (105) | 12.5 ± 0.6 (116) | 12.6 ± 0.4 (117) |
Data are mean ± S.E.M. values (N = 7 rats/group) for binding [fmol/mg of tissue and (percentage of control)], determined by quantitative autoradiography following continuous subcutaneous infusion of vehicle or antipsychotic drugs for 4 weeks, all as described under Experimental Procedures. No statistically significant drug effect was found.
↵1-a Data (percentage of control) for clozapine (40 mg/kg/day) and fluphenazine (1 mg/kg/day) were determined previously (Tarazi et al., 1998) and are shown for comparison.