Apparent K i values (nM) of BUP and norBUP for the opioid receptors and the ORL1 receptor
| μ | δ | κ | ORL1 | |
|---|---|---|---|---|
| BUP | 0.08 ± 0.02 (n = 4) | 0.42 ± 0.04 (n = 4) | 0.11 ± 0.05 (n = 4) | 285 ± 30 (n = 3) |
| NorBUP | 0.07 ± 0.01 (n = 4) | 3.14 ± 0.30 (n = 4) | 0.91 ± 0.14 (n = 6) | 7330 ± 2884 (n = 3) |
Apparent K i values were calculated from the equationK i = IC50/(1 +[L]/K d); IC50 values were derived from the competition curves shown in Fig. 2. Each value represents the mean ± S.E.M. n = number of independent experiments performed in duplicate.