Table 3

AcSDKP concentrations in plasma from mice treated with RXP 407 and lisinopril

TreatmentAcSDKP3-a
15 min3-b30 min3-b45 min3-b60 min3-b
pmol/ml
Control0.9 (0.5–1.2)3-c 0.9 (0.6–1.3)3-c 0.9 (0.5–1.3)3-c 1.1 (0.6–1.8)3-c
RXP 407
 0.1 mg/kg1.2 (0.7–2.0)3-c 1.1 (0.7–1.9)3-c 1.5 (0.8–2.8)3-c 3-d 1.6 (0.9–6.9)3-c 3-d
 0.5 mg/kg1.4 (0.7–4.3)2.3 (1.6–3.6)3-c 3-d 1.6 (1.2–2.7)3-c 3-d 2.2 (1.5–5.7)3-c 3-d
 1 mg/kg1.6 (1.1–2.4)2.4 (1.4–7.7)3-c 3-d 2.4 (1.2–8.6)3-c 3-d 2.4 (1.2–10.2)3-c 3-d
 10 mg/kg1.7 (1.1–2.8)3.3 (2.4–3.9)3-c 3-d 4.3 (2.5–15.9)3-c 3-d 6.2 (2.5–30.8)3-c 3-d
 30 mg/kg1.9 (1.3–2.4)3-d 2.7 (2.1–3.4)3-c 3-d 4.0 (1.9–11.7)3-c 3-d 3.8 (2.4–5.7)3-c 3-d
Lisinopril
 5 mg/kg2.8 (2.1–3.6)3-d 4.3 (1.0–7.3)3-c 3-d 8.4 (4.3–12.5)3-d 7.9 (1.1–31.7)3-c 3-d
 10 mg/kg2.4 (1.7–3.3)3-d 5.4 (2.7–9.9)3-d 7.1 (2.8–14.5)3-d 13.2 (7.5–26.2)3-d

  • ↵3-a  Expressed as geometric mean (range) (n = 8).

  • ↵3-b  After the infusion start.

  • ↵3-c  p < 0.05 versus 10 mg/kg lisinopril by Student-Newman-Keuls test.

  • ↵3-d  p < 0.05 versus control group by Student-Newman-Keuls test.