Table 3

Effect of stavudine on blood or plasma metabolic substrates and lipids in lean mice fasted for 48 h

	Glucose	Lactate	β-OH-Butyrate	Acetoacetate	β-OH-Butyrate/ Acetoacetate Ratio	FFA	TG	TC	PL
	g/l	mmol/l	mmol/l	mmol/l		mmol/l	mmol/l	mmol/l	mmol/l
Controls (n)	0.60 ± 0.04 (10)	4.45 ± 0.49 (9)	1.43 ± 0.17 (12)	0.41 ± 0.04 (12)	3.49 ± 0.19 (12)	2.67 ± 0.12 (10)	1.07 ± 0.08 (29)	5.08 ± 0.12 (13)	4.22 ± 0.06 (13)
Stavudine (n)	0.50 ± 0.04 (10)	3.60 ± 0.26 (9)	2.96 ± 0.34^3-160 (11)	0.71 ± 0.07^3-160 (11)	4.17 ± 0.30^3-150 (11)	2.33 ± 0.15 (10)	1.20 ± 0.05 (32)	5.00 ± 0.16 (13)	4.31 ± 0.14 (13)

Lean mice were treated with stavudine (100 mg/kg/day) for 6 weeks and fasted for the last 48 h. Glucose and lactate were measured on whole blood, whereas β-hydroxybutyrate (β-OH-butyrate), acetoacetate, free fatty acids (FFA), triglycerides (TG), total cholesterol (TC), and phospholipids (PL) were assessed in plasma. Results are means ± S.E.M. for the number of mice specified in the parentheses.

Asterisks indicate significant differences between control and treated mice (
↵3-150 P < 0.05;
↵3-160 P < 0.01).