Table 2

Concentration-dependent effects of chloroquine on different ionic currents

Current	Drug Concentration (μM)
Current	0.3	1	3	10
I_Na	4 ± 2	^2-15014 ± 3 (n = 4)	^2-15025 ± 4 (n = 4)	^2-15045 ± 5 (n = 5)
I_Ca-L	2 ± 1	^2-1507 ± 2 (n= 3)	^2-1509 ± 3 (n = 4)	^2-15032 ± 4 (n = 5)
I_K1	^2-15051 ± 10	^2-15074 ± 9 (n = 7)	^2-15086 ± 7 (n = 8)	^2-15096 ± 3 (n = 6)
I_to	2 ± 1	2 ± 1 (n = 4)	3 ± 2 (n = 4)	4 ± 3 (n = 4)
I_K(tail)	^2-15021 ± 4	^2-15038 ± 5 (n = 7)	^2-15065 ± 7 (n = 9)	^2-15070 ± 6 (n = 7)
I_Ks(tail)	7 ± 5	9 ± 5 (n = 5)	7 ± 4 (n = 5)	^2-15011 ± 5 (n = 5)

Numbers refer to percentage of block. I_Na was measured at −40 mV, holding potential (HP) = −120 mV; I_Ca-L was measured at ⁺10 mV, HP = −70 mV; I_K1 was measured at the HP of −60 mV; I_to was measured at ⁺50 mV, HP = −60 mV; I_K(tail) was measured at −40 mV following an activating pulse to ⁺50 mV; I_Ks(tail) was measured at −40 mV following an activating pulse to ⁺50 mV.

↵2-150 Statistically significant (p < 0.05).