Lymphoblast RAF estimates for CYPs 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, and 3A4 in human liver microsomes and SUPERMIX
| CYP Isoform | RAF for Human Livers | RAF for SUPERMIX |
|---|---|---|
| 1A2 | 123.7 | 217.3 |
| (57–282) | ||
| [101–152] | ||
| 2B6 | 160.5 | 0 |
| (18–756) | ||
| [30–555] | ||
| 2C8 | 79.2 | 194.5 |
| (21–179) | ||
| [51–119] | ||
| 2C9 | 53.5 | 169 |
| (33–78) | ||
| [49–57] | ||
| 2C19 | 29 | 20.8 |
| (4–45) | ||
| [20–40] | ||
| 2D6 | 8.0 | 22.6 |
| (3–30) | ||
| [6–13] | ||
| 3A4 | 254.1 | 291 |
| (101–1050) | ||
| [165–583] |
n = 12 human livers for CYPs 1A2, 2B6, 2C8, 2C9, and 3A4; n = 10 human livers for CYP2C19 (poor metabolizer livers L11 and L12 excluded); n = 11 human livers for CYP2D6 (poor metabolizer liver L8 excluded). Bolded table entries are sample medians, with range of values in parentheses and interquartile range in brackets. RAF values are in picomoles per milligram of microsomal protein.