Effect of l-NAME (10 mg/kg) alone and in combination with NCX 4016 (NCX, 100 mg/kg) on basal MAP, body height (BW), left ventricular weight (LVW), area at risk (AAR), infarct size, and mortality in rats subjected to 30 min of coronary artery occlusion followed by 120 min of reperfusion
| Group | MAP | BW | LVW | AAR | Infarct Size | Mortality |
|---|---|---|---|---|---|---|
| mm Hg | g | mg | % of LVW | % of AAR | % | |
| Sham (n = 10) | 97 ± 5 | 310 ± 12 | 522 ± 32 | 0 | ||
| Vehicle + MI/R (n = 14) | 100 ± 3 | 306 ± 9 | 508 ± 23 | 53.8 ± 2.6 | 54.7 ± 2.0 | 29 |
| NCX + MI/R (n = 10) | 98 ± 4 | 308 ± 7 | 514 ± 21 | 52.2 ± 1.6 | 24.5 ± 3.65-165 | 0 |
| L-NAME + MI/R (n = 18) | 142 ± 55-160 | 305 ± 8 | 503 ± 30 | 54.4 ± 2.8 | 68.2 ± 1.55-150 | 44 |
| NCX + l-NAME + MI/R (n = 11) | 107 ± 45-a | 307 ± 13 | 519 ± 25 | 52.7 ± 3.4 | 33.9 ± 2.35-150 5-b | 9 |
Drugs and vehicle (2 ml/kg PEG 400) were given orally for 5 consecutive days. Data are expressed as mean ± S.E. In parentheses, number of experiments. Sham-operated animals were treated with vehicle.