Effects of eugeniin on virus yields in the skin and brain of mice infected with wild-type HSV-1 at 106 PFU/mouse
| Days after Infection | Treatment Dose | Mean ± S.D. Virus Yield3-a | Skin/Brain3-b | |
|---|---|---|---|---|
| Skin | Brain | |||
| mg/kg | log10PFU/organ | |||
| Expt. 1 | ||||
| 3 | ||||
| Control (water) | 6.3 ± 0.1 (100)3-c | N.D. | ||
| Eugeniin | 0.3 | 6.0 ± 0.2 (95.2) | N.D. | |
| 3 | 6.2 ± 0.3 (98.4) | N.D. | ||
| 10 | 5.9 ± 0.1 (93.7)3-d | N.D. | ||
| 6 | ||||
| Control (water) | 6.3 ± 0.1 (100) | 3.8 ± 0.5 (100) | 1.00 | |
| Eugeniin | 0.3 | 6.6 ± 0.2 (104.8) | 3.8 ± 0.3 (100) | 1.05 |
| 3 | 5.2 ± 0.9 (82.5) | 3.1 ± 1.0 (81.6) | 1.01 | |
| 10 | 5.7 ± 0.2 (90.5)3-d | 3.0 ± 0.9 (78.9) | 1.15 | |
| Expt. 2 | ||||
| 6 | ||||
| Control (water) | 6.3 ± 0.4 (100) | 2.2 ± 0.4 (100) | 1.0 | |
| Eugeniin | 1 | 6.7 ± 0.3 (106.3) | 2.1 ± 0.3 (95.5) | 1.11 |
| 50 | 6.0 ± 0.2 (95.2) | <1.3 ± 0.0 (<59.1)3-d | >1.61 | |
Eugeniin was orally administered and examined for antiviral activity against HSV-1 in the skin and brain of the infected mice on days 3 and 6 after infection as described in the text.
N.D., not detected.
↵3-a Virus yields represent the geometric mean ± S.D. per organ of three mice in each group.
↵3-b Skin/brain represents the ratio of percentage virus yields of the skin over the brain for each treatment.
↵3-c Numbers in parentheses represent percentage virus yields.
↵3-d p < 0.01 versus control by Student's t test.