Rank order of the magnitude of effect of ester homologs of amiodarone on several electrophysiological parameters of cardiac conduction and ventricular repolarization in guinea pig isolated heart
| Parameter | Rank Order |
|---|---|
| St-A | ATI-2001 > ATI-2042 > ATI-2054 > ATI-2064 > ATI-2010 = metabolite |
| AH | ATI-2001 = ATI-2064 = ATI-2042 > ATI-2010 = ATI-2054 > metabolite |
| HV | ATI-2064 = ATI-2001 > metabolite = ATI-2042 = ATI-2010 = ATI-2054 |
| QRS | ATI-2001 > ATI-2064 > ATI-2042 = ATI-2010 = ATI-2054 = metabolite |
| QT | ATI-2042 = ATI-2001 > ATI-2064 = ATI-2010 > ATI-2054 = metabolite |
| MAPD90 | ATI-2042 ≥ ATI-2001 = ATI-2010 = ATI-2064 > ATI-2054 ≥ metabolite |