Doses of κ-agonists required to produce 50% enadoline lever-responding alone and after nor-BNI (10 mg/kg) administration
| Drug | ED50 for Enadoline-Discrimination (mean ± 95% CI) | |
|---|---|---|
| Drug Alone | Drug after 10 mg/kg nor-BNI | |
| Enadoline | 0.0004 (0.0002–0.0009) | 0.005 (0.003–0.009) |
| U 50,488 | 0.11 (0.08–0.13) | 0.71 (0.11–4.76) |
| Bremazocine | 0.00173 (0.00172–0.00174) | 0.02 (0.016–0.029) |
| EKC | 0.011 (0.010–0.011) | 0.02 (0.004–0.1) |
Values are data for three monkeys (mean ± 95% CI). Antagonism data are taken from day 6 (enadoline), day 18 (U 50,488), day 23 (bremazocine), and day 25 (EKC) following nor-BNI administration.