Drug | Enadoline Discrimination | Relative Potency to Reduce Electrically Evoked Contraction in Rabbit Vas Deferens1-a | |
---|---|---|---|
ED50 (±1 S.E.M.) | Relative Potency | ||
mg/kg | |||
Enadoline | 0.0006 ± 0.0001 | 1.0 | 1.0 |
GR 89696A | 0.0006 ± 0.0001 | 1.0 | 0.031-b |
Bremazocine | 0.0018 ± 0.0002 | 4.4 | 3.1 |
EKC | 0.008 ± 0.003 | 13.3 | 6.8 |
(−)-Spiradoline | 0.03 ± 0.012 | 50 | 8.7 |
PD 117,302 | 0.07 ± 0.014 | 115 | 17.6 |
U 50,488 | 0.13 ± 0.02 | 217 | 67 |
EMD 61753 | 0.18 ± 0.03 | 300 | 16.5 |
ICI 204,448 | 1.22 ± 0.52 | 2003 | 4.51-c |
ED50 values for enadoline-discrimination are calculated by linear interpolation and, for each drug, are means ± S.E.M. of values obtained in three to four monkeys.