Doses of YM976, rolipram, theophylline, and prednisolone effective against antigen-induced immediate bronchoconstriction, airway plasma leakage, and lung eosinophil infiltration in sensitized guinea pigs
| Compound | ED50 Value | ||
|---|---|---|---|
| Bronchoconstriction | Plasma Leakage | Eosinophil Infiltration | |
| mg/kg, p.o. | |||
| YM976 | 7.3 (4.5–11) | 5.7 (1.3–28) | 1.0 (0.43–1.8) |
| Rolipram | 7.7 (3.7–14) | 3.0 (1.3–5.1) | 3.6 (1.1–7.8) |
| Theophylline | 67 (27–110) | 16 (8.4–28) | >100 |
| Prednisolone | >100 | >1001-150 | 5.1 (1.7–14) |
These airway responses were elicited by the inhalation of antigen in sensitized guinea pigs. The data of the saline group and the OA group were defined as 100 and 0% inhibitory effects, respectively. Each ED50 value was calculated as the dose causing 50% inhibition of each response by linear regression (maximum-likelihood method) using SAS. Each group comprised five to eight animals. The values in parentheses represent 95% confidence limits.
↵1-150 46% inhibition at 100 mg/kg, p.o.