Table 1

Structural models evaluated to describe the disposition of VPA and VG in the presence and absence of PRB

Model	Parameters Describing the Disposition of VPA and VG^1-a
Model	A	B	C	D	E	F
1	K_sp	K_cp	K_fo	K_fg	K_sg	K_cg
2	N.A.	K_cp	K_fo	K_fg	K_sg	K_cg
3	N.A.	K_cp	K_fo	K_fg	K_sg	V^o _max,cg
4	N.A.	K_cp	K_fo	K_fg	K_sg	K_m,cgV_max,cg
5	N.A.	K_cp	K_fo	K_m,fgV_max,fg	K _sg	K_cg
6	N.A.	K_cp	K_fo	K_m,fgV_max,fg	K_sg	V^o _max,cg
7	N.A.	K_cp	K_fo	K_m,fgV_max,fg	K_sg	K_m,cgV_max,cg
8	N.A.	K_cp	K_m,foV_max,fo	K_fg	K_sg	K_cg
9	N.A.	K_cp	K_m,foV_max,fo	K_fg	K_sg	V^o _max,cg
10	N.A.	K_cp	K_m,foV_max,fo	K_fg	K_sg	K_m,cgV_max,cg

K_sp, first-order rate constant for sinusoidal uptake of parent; K_cp, first-order rate constant for canalicular egress of parent; K_fo, first-order formation rate constant for oxidative metabolites; K_m,fo, Michaelis-Menten constant for formation of oxidative metabolites; V_max,fo, maximal formation velocity of oxidative metabolite; K_fg, first-order formation rate constant for VG; K_m,fg, Michaelis-Menten constant for formation of VG; V_max,fg, maximal formation of VG; K_sg, first-order rate constant for sinusoidal egress of VG; K_cg, first-order rate constant for canalicular egress of VG; V^o_max,cg, zero-order rate constant for canalicular egress of VG; K_m,cg, Michaelis-Menten constant for canalicular egress of VG; V_max,cg, maximal velocity for canalicular egress of VG; N.A., not applicable to that particular model.
↵1-a Refer to scheme in Fig. 1.