Pharmacokinetic parameter estimates of naproxen given orally at doses of 1.7, 3.2, and 10 mg/kg to rats
| Parameter | Estimate | IAV |
|---|---|---|
| V(ml/kg) | 164 (0.16) | 16 (0.34) |
| CL (ml/h/kg) | 33.6 (0.21) | 20 (0.44) |
| K A(1/h) | 14.82 (0.08) | 50 (0.48) |
| F (1.7 mg/kg) | 1 FIX | N.E. |
| F (3.2 mg/kg) | 0.8 (0.9) | N.E. |
| F (10 mg/kg) | 0.77 (0.1) | N.E. |
Estimates of interanimal (IAV) variability are expressed as coefficients of variation (%). Precision of the estimates is expressed as relative standard error in parentheses. Relative standard error is standard error divided by the parameter estimate.
V, volume of distribution; CL, total plasma clearance;KA, first order rate constant of absorption;F, bioavailability; N.E., not estimated in the model; FIX, fixed parameter.