Inactivation of b6G-resistant mutant AGTs by b6G and oligodeoxyribonucleotides
| AGT Used | ED50 Value | ||
|---|---|---|---|
| b6G | 5′-d(TmpGTGAb6- GCTGTmpG)-3′ (11-mpBG-1) | 5′-d(AACAGCC- ATATb6- GGCCC)-3′ | |
| nM | |||
| Wild type | 400 | 1.3 | 1.1 |
| G160R | 9,000 | 9.5 | 6.5 |
| K165A | 27,000 | 20 | 20 |
| G156A | 60,000 | 8 | 6 |
| Y158H | 620,000 | 56 | 13 |
| P140K | >1,2000,000 | 150 | 24 |