Table 5
Plasma protein binding
Compound
Albumin (
K
d
)
Rat Whole Plasma Binding Capacity
μM
% Bound
ISIS 2302-PS ODN
17.7
99.2
ISIS 14725-PS MOE-partial
39.4
97.6
ISIS 11159-PS MOE-full
29.3
95.5
ISIS 16952-PO MOE-full
672
79.6
ISIS 18268-PS/PO MOE-full
237
88