Table 5

Plasma protein binding

CompoundAlbumin (Kd)Rat Whole Plasma Binding Capacity
μM % Bound
ISIS 2302-PS ODN17.799.2
ISIS 14725-PS MOE-partial39.497.6
ISIS 11159-PS MOE-full29.395.5
ISIS 16952-PO MOE-full67279.6
ISIS 18268-PS/PO MOE-full23788