Urine excretion
| Compound | %Radiolabel Dose Excreted | % Dose Excreted as Oligonucleotide4-a |
|---|---|---|
| ISIS 2302-PS ODN | 32.1 ± 0.53 | 0.3 |
| ISIS 14725-PS MOE-partial | 34.6 ± 7.02 | 3.2 |
| ISIS 11159-PS MOE-full | 11.2 ± 6.08 | 9.4 |
| ISIS 16952-PO MOE-full | 48.1 ± 11.6 | 45 |
| ISIS 18268-PS/PO MOE-full | 20.1 ± 2.54 | 16 |
↵4-a As measured by strong anion exchange-HPLC/UV/liquid scintillation counting.