Mean ED50 values (±1 S.E.M.) for the antinociceptive effects of drugs in combination with 0.1 mg of capsaicin, 0.0158 mg of PGE2, or 10% FCA injected into the tail of monkeys
| Drug | +Capsaicin | +PGE2 | +FCA |
|---|---|---|---|
| SNC80 | 3.87 ± 1.27 | 0.78 ± 0.13 | 0.56 ± 0.01 |
| SNC243A | 3.07 ± 0.88 | ||
| SNC162 | 3.68 ± 0.99 | ||
| SNC86 | N.D. | ||
| SNC67 | N.D. | ||
| Morphine | 0.12 ± 0.03 | ||
| Ketorolac | N.D. |
All values show mean data from three monkeys except SNC80 in combination with 10% FCA, which shows mean data from two monkeys.
N.D., could not be determined. See text for details.