Pharmacokinetic variables for recirculatory antipyrine pharmacokinetics
| Experimental Condition | Volumes4-a | Clearances4-b | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| VC | VT-P | VND | VT-F | VT-S | VSS | CLND | CLT-F | CLT-S | CLE | ΣCL | |
| liters | l/min | ||||||||||
| Control | 0.87 (0.16) | 0.14 (0.04) | 0.13 (0.04) | 8.30 (0.66) | 16.76 (4.32) | 26.19 (4.89) | 0.74 (0.32) | 3.00 (0.44) | 0.79 (0.10) | 0.23 (0.08) | 4.76 (0.72) |
| Isoproterenol | 1.02 (0.18) | 0.18 (0.02) | 0.424-c(0.14) | 13.214-c (1.99) | 14.21 (2.14) | 29.04 (3.28) | 1.474-c(0.27) | 8.374-c (1.89) | 0.78 (0.35) | 0.304-c(0.06) | 10.934-c (2.07) |
| Nitroprusside | 0.71 (0.10) | 0.12 (0.04) | 0.12 (0.02) | 5.524-c (1.90) | 18.88 (5.17) | 25.35 (3.99) | 0.91 (0.40) | 3.19 (0.83) | 1.194-c (0.25) | 0.25 (0.09) | 5.55 (0.95) |
| Phenylephrine | 0.82 (0.11) | 0.11 (0.05) | 0.20 (0.09) | 4.144-c(1.76) | 18.56 (3.77) | 23.83 (4.95) | 0.73 (0.33) | 1.264-c (0.44) | 0.58 (0.16) | 0.22 (0.06) | 2.784-c(0.86) |
Values are mean (±S.D.).
↵4-a Shown are the volumes (V) of the central (described by ICG and inulin) circuit (C), pulmonary tissue (the difference between the antipyrine central circuit volume and that described by ICG and inulin) (T-P), nondistributive (ND) circuit, and the rapidly equilibrating (fast) (T-F) and slowly equilibrating (T-S) tissues, and the volume of distribution at steady-state (VSS), which equals the sum of all volumes.
↵4-b Shown are the clearances (CL) of the nondistributive (ND) circuit and the rapidly equilibrating (fast) (T-F) and slowly equilibrating (T-S) tissues, elimination clearance (CLE), and the sum of all clearances (ΣCL), which equals the ICG (dye dilution) cardiac output determined at the moment of marker injection.
↵4-c Significantly different from control (p < 0.05), as determined by Fisher's LSD test.