Antagonists | Rat Cardiac Fibroblasts | Human Skin Fibroblasts | |||
---|---|---|---|---|---|
α8β1 | α3/5/vβ1 | αvβ3 | αvβ1 | αvβ3 | |
Echistatin | 0.0036 ± 0.001 | 0.0084 ± 0.0054 | 0.0034 ± 0.001 | 0.0035 ± 0.0005 | 0.0034 ± 0.0006 |
Eptifibatide | >100 | >100 | 10.7 ± 1.3 | >100 | 20 ± 8.6 |
L-734,217 | N.D. | N.D. | N.D. | N.D. | N.D. |
Lamifiban | N.D. | N.D. | N.D. | N.D. | N.D. |
Ro 44-3888 | N.D. | N.D. | N.D. | N.D. | N.D. |
SR 121566A | N.D. | N.D. | N.D. | N.D. | N.D. |
XJ735 | >100 | >100 | 30.6 ± 3.8 | 82 ± 4.5 | 6.6 ± 0.93-150 |
DMP728 | N.D. | N.D. | 3.3 ± 0.2 | >100 | 9.2 ± 1.7 |
BIBU-52 | N.D. | N.D. | N.D. | N.D. | N.D. |
SC-54701A | N.D. | N.D. | N.D. | N.D. | N.D. |
XV459 | N.D. | N.D. | N.D. | N.D. | N.D. |
ReoPro | N.D. | N.D. | N.D. | N.D. | 0.22 ± 0.24 |
Results are the means ± S.E.M. of three different experiments.
N.D., no significant displacement of 125I-echistatin.
↵3-150 p ≤ 0.05 versus human αvβ1 integrin.